The chiral pyridoxal-catalyzed biomimetic Mannich reaction: the mechanism and origin of stereoselectivity
Lili Han, Qiaoyu Zhang, Xue Li, Yan Qiao, Yu Lan, Donghui Wei
Abstract
A biomimetic organocatalyst with a pyridoxal-like structure is one of the most successful examples of catalyzing organic reactions under mild conditions in an asymmetric synthesis field.
Topics & Concepts
ChemistryPyridoxalStereoselectivityMannich reactionCatalysisMechanism (biology)Biomimetic synthesisCombinatorial chemistryOrganic chemistryStereochemistryEnzymePhilosophyEpistemologyAsymmetric Synthesis and CatalysisChemical Synthesis and AnalysisSynthetic Organic Chemistry Methods