Female mice lacking ERβ display excitatory/inhibitory synaptic imbalance to drive the pathogenesis of temporal lobe epilepsy
Zhongke Wang, Ruxin Xie, Xiaolin Yang, Huachun Yin, Xin Li, Tianyao Liu, Yuanyuan Ma, Junwei Gao, Zhenle Zang, Ruotong Ruan, Li Yang, Kaixuan Huang, Qingbo Chen, Kai‐Feng Shen, Shengqing Lv, Chunqing Zhang, Hui Yang, Maragret Warner, Jan-Ακε Gustafsson, Shiyong Liu, Xiaotang Fan
Abstract
Our data provide novel insight into the pathogenesis of female TLE, and indicate ERβ provides a new therapeutic strategy for female TLE patients.
Topics & Concepts
EpilepsyExcitatory postsynaptic potentialInhibitory postsynaptic potentialNeuroscienceNeuroprotectionTemporal lobeEstrogenEstrogen receptorPathogenesisMedicineMechanism (biology)BiologyEndocrinologyInternal medicinePhysicsBreast cancerQuantum mechanicsCancerNeuroscience and Neuropharmacology ResearchPharmacological Effects and Toxicity StudiesEpilepsy research and treatment