Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy
Elodie Renaude, Marie Kroemer, Christophe Borg, Paul Peixoto, Éric Hervouet, Romain Loyon, Olivier Adotévi
Abstract
Evidences highlight the role of various CD4 + helper T cells (CD4 + Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4 + Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4 + T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4 + Th responses by epigenetic drugs to improve anticancer immunotherapy.
Topics & Concepts
EpigeneticsReprogrammingImmunotherapyTumor microenvironmentBiologyImmune systemCancer immunotherapyImmunologyCancer researchImmunityGeneticsCellGeneCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune cells in cancer