A role for complement blockade in kidney transplantation
Diana Karpman, Zivile Békássy, Anne Grünenwald, Lubka T. Roumenina
Abstract
Kidney transplantation is a life-saving procedure for patients with end-stage renal failure, but unfortunately, only a limited number of patients benefit from this procedure due to organ shortage. Moreover, even after transplantation, the graft can be lost due to antibody-mediated rejection (AMR). A recent study by Schmitz et al. in Nature Communications [1] provides new hope to prevent AMR and prolong renal allograft survival. The authors inhibited the innate immune complement cascade at the level of its central component C3 and successfully prevented the tissue injury mediated by donor-specific antibodies (DSAs) in a primate model.
Topics & Concepts
TransplantationBlockadeEconomic shortageKidney transplantationMedicineComplement systemKidneyImmunologyComplement (music)AntibodyInnate immune systemImmune systemBiologyReceptorInternal medicinePhenotypeGovernment (linguistics)GeneLinguisticsComplementationBiochemistryPhilosophyRenal Transplantation Outcomes and TreatmentsComplement system in diseasesRenal Diseases and Glomerulopathies