<i>In situ</i> vaccination caused by diverse irradiation-driven cell death programs
Yi‐Jun Wang, Yan Li, Yuxin Yang, Michelle Swift, Zhenyu Zhang, Shuhui Wu, Yajie Sun, Kunyu Yang
Abstract
vaccine. In this review, we provide fundamental knowledge of various forms of ICD caused by irradiation, describe the relationship between various cell death pathways and the immune activation effect driven by irradiation, and focus on the therapeutic value of exploiting these cell death programs in the context of irradiation. Furthermore, we summarize the immunomodulatory effect of different cell death programs on combinative radiotherapy and immunotherapy. In brief, differences in cell death programs significantly impact the irradiation-induced immune activation effect. Evaluating the transition between them will provide clues to develop new strategies for radiotherapy and its combination with immunotherapy.