Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascade
Jiancheng Lv, Qikai Wu, Kai Li, Kexin Bai, Hao Yu, Juntao Zhuang, Huanyou Sun, Haiwei Yang, Xiao Yang, Qiang Lü
Abstract
Taken together, SETD7 indicated poor prognosis and promoted the progression and immune escape of BCa cells. It has great potential to act as a new indicator for BCa diagnosis and treatment, especially immunotherapy.
Topics & Concepts
CarcinogenesisMethyltransferaseCancer researchImmune systemBladder cancerWestern blotImmunotherapyMethylationCD8BiologyMolecular biologyCancerImmunologyGeneGeneticsEpigenetics and DNA MethylationBladder and Urothelial Cancer TreatmentsCancer-related gene regulation