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Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock

Hongchen Zhang, Shipeng Shao, Yong Zeng, Xiaotian Wang, Yizhi Qin, Qiunan Ren, ShengQi Xiang, Yuxin Wang, Junyu Xiao, Yujie Sun

2022Nature Cell Biology173 citationsDOI

Topics & Concepts

HSF1Heat shock factorHeat shockHeat shock proteinCell biologyHsp70Transcription factorHSPA4BiologyTranscription (linguistics)GeneChemistryGeneticsPhilosophyLinguisticsHeat shock proteins researchRNA Research and Splicingthermodynamics and calorimetric analyses
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock | Litcius