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Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease

Jun Kai, Yang Xiang, Zhimin Wang, Feixia Wang, Yan Jia, Shijun Wang, Shanzhong Tan, Anping Chen, Jiangjuan Shao, Feng Zhang, Zili Zhang, Shizhong Zheng

2020Free Radical Biology and Medicine106 citationsDOI

Topics & Concepts

MFN2PyroptosisBlocking (statistics)Cell biologyMitochondrial ROSChemistryAlcoholic liver diseaseHepatocyteMitochondrionApoptosisMedicineBiologymitochondrial fusionProgrammed cell deathBiochemistryComputer scienceMitochondrial DNACirrhosisInternal medicineGeneIn vitroComputer networkInflammasome and immune disordersAlcohol Consumption and Health EffectsGout, Hyperuricemia, Uric Acid
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease | Litcius