Design of a multi-epitope-based vaccine targeting M-protein of SARS-CoV2: an immunoinformatics approach
Vijaya Sai Ayyagari, T. C. Venkateswarulu, K. Abraham Peele, Krupanidhi Srirama
Abstract
into pET-28a (+). Immune simulation studies showed the induction of primary, secondary and tertiary immune responses marked by the increased levels of antibodies, INF-γ, IL-2, TGF-β, B- cells, CD4+ and CD8+ cells. Finally, the vaccine construct was able to elicit immune response as desired.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
EpitopeImmunogenicityAdjuvantAntigenVirologyImmune systemBiologyPopulationProtein tertiary structureEpitope mappingIn silicoComputational biologyImmunologyMedicineGeneticsGeneBiochemistryEnvironmental healthvaccines and immunoinformatics approachesMonoclonal and Polyclonal Antibodies ResearchSARS-CoV-2 and COVID-19 Research