A multiscale screening strategy for the identification of novel xanthine oxidase inhibitors based on the pharmacological features of febuxostat analogues
Na Zhai, Yanming Chen, Chenchen Wang, Fengshou Wu, Xiaogang Luo, Xiu-Lian Ju, Hui Liu, Genyan Liu
Abstract
Two compounds as potential XOI hits were identified by a novel screening strategy based on the pharmacophores of well-known scaffolds.
Topics & Concepts
FebuxostatChemistryXanthine oxidaseIdentification (biology)Xanthine oxidase inhibitorUric acidBiochemistryPharmacologyHyperuricemiaComputational biologyCombinatorial chemistryEnzymeBiologyMedicineBotanyNatural product bioactivities and synthesisGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural Compounds