Crown Ether Functionalized Potassium‐Responsive Anionocages for Cascaded Guest Delivery
Shanshan Wang, Zhe Huang, Anyang Li, Yanxia Zhao, Wei Zuo, Yawen Li, Haohao Miao, Jiacheng Ma, Wei Sun, Xiaoqing Wang, Liping Cao, Biao Wu, Chuandong Jia
Abstract
Abstract In many critical biological processes, host–guest chemistry of protein receptors is regulated by effector molecules to realize cascaded delivery of messenger molecules between different targets. Mimicking these natural processes with artificial receptors remains a challenge. Herein, we report a cascaded guest delivery between two anionocages (anion‐coordination‐driven cages), in a reversible manner, wherein binding of K + ions by a crown ether functionalized, heteroleptic A 2 L 3 (A=anion, L=ligand) anionocage triggers the release and delivery of a TEA + (tetraethylammonium) guest to another A 2 L 3 anionocage that is a weaker and less K + ‐sensitive receptor. Elimination of the K + with [2,2,2]‐cryptand enables recapture of the TEA + by the crown ether functionalized anionocage and thus realizes a reversed guest delivery. Moreover, integrative self‐sorting of anionocages is firstly reported, leading to heteroleptic cages with enhanced guest binding affinities.