Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways
Jerry T. Dang, Valentin Mocanu, Heekuk Park, Michael Laffin, Naomi Hotte, Shahzeer Karmali, Daniel W. Birch, Karen Madsen
Abstract
was decreased, which correlated with decreased weight, insulin resistance, and systemic inflammation. This work represents comprehensive analyses of microbial-metabolomic changes that occur following bariatric surgery and identifies several pathways that are associated with beneficial metabolic effects of surgery.
Topics & Concepts
Weight lossMetabolomicsFirmicutesSleeve gastrectomyBiologyGut floraInsulin resistanceMetabolic syndromeProteobacteriaPhysiologyGastric bypassInternal medicineGastroenterologyObesityBioinformaticsEndocrinologyMedicineBacteriaImmunology16S ribosomal RNAGeneticsGut microbiota and healthDiet and metabolism studiesBariatric Surgery and Outcomes