Manganese-Catalyzed Hydrogenation of Ketones under Mild and Base-free Conditions
Stefan Weber, Julian Brünig, Luı́s F. Veiros, Karl Kirchner
Abstract
)]. The reaction proceeds at room temperature under base-free conditions with a catalyst loading of 3 mol % and a hydrogen pressure of 10 bar. A temperature-dependent selectivity for the reduction of α,β-unsaturated carbonyls was observed. At room temperature, the carbonyl group was selectively hydrogenated, while the C=C bond stayed intact. At 60 °C, fully saturated systems were obtained. A plausible mechanism based on DFT calculations which involves an inner-sphere hydride transfer is proposed.
Topics & Concepts
ChemistryCatalysisHydrideAlkylManganeseSelectivityHydrogenTransfer hydrogenationHomogeneousBase (topology)Noyori asymmetric hydrogenationMedicinal chemistryHomogeneous catalysisPolymer chemistryPhotochemistryOrganic chemistryThermodynamicsPhysicsMathematicsRutheniumMathematical analysisAsymmetric Hydrogenation and CatalysisCatalysts for Methane ReformingCatalysis for Biomass Conversion