SuFEx-enabled, chemoselective synthesis of triflates, triflamides and triflimidates
Bing‐Yu Li, Lauren Voets, Ruben Van Lommel, Fien Hoppenbrouwers, Mercedes Alonso, Steven H. L. Verhelst, Wim M. De Borggraeve, Joachim Demaerel
Abstract
Triflyl fluoride gas (CF 3 SO 2 F) and its aza analogues are reported as new SuFEx activators. These S VI –F reagents react efficiently with a variety of nucleophiles, yet the presence of water grants complete chemoselectivity to phenols.
Topics & Concepts
Combinatorial chemistryChemistryComputer scienceChemical Synthesis and AnalysisFluorine in Organic ChemistryChemical Synthesis and Reactions