Development and characterization of pellets for targeted delivery of 5-fluorouracil and phytic acid for treatment of colon cancer in Wistar rat
Veerpal Kaur, Amit K. Goyal, Goutam Ghosh, Sudam Chandra, Goutam Rath
Abstract
in the finished formulation, indicates lower systemic exposure to the drug. X-ray radiography ensures the localized delivery of the encapsulated drug. Histopathological studies indicated no significant local toxicity compared to the uncoated formulation. Results inferred that the proposed combination has superior anticancer activity with minimum systemic and local toxicity and it opens a new avenue in the treatment of colorectal cancer.
Topics & Concepts
PharmacokineticsPharmacologyBioavailabilityPhytic acidCmaxDrug deliveryIn vivoPharmacodynamicsColorectal cancerDrugChemistryMedicineCancerBiochemistryInternal medicineBiologyBiotechnologyOrganic chemistryPhytase and its ApplicationsDrug Transport and Resistance MechanismsOral and gingival health research