The Role of Cytokines in Cholesterol Accumulation in Cells and Atherosclerosis Progression
Alexander M. Markin, Yuliya V. Markina, Anastasia I. Bogatyreva, Taisiya V. Tolstik, D. А. Chakal, D.G. Breshenkov, E. R. Charchyan
Abstract
Atherosclerosis is the most common cardiovascular disease and is the number one cause of death worldwide. Today, atherosclerosis is a multifactorial chronic inflammatory disease with an autoimmune component, accompanied by the accumulation of cholesterol in the vessel wall and the formation of atherosclerotic plaques, endothelial dysfunction, and chronic inflammation. In the process of accumulation of atherogenic lipids, cells of the immune system, such as monocytes, macrophages, dendritic cells, etc., play an important role, producing and/or activating the production of various cytokines-interferons, interleukins, chemokines. In this review, we have tried to summarize the most important cytokines involved in the processes of atherogenesis.