Total synthesis of Palmarumycin BGs, C<sub>1</sub>and Guignardin E
Xinlei Liu, Shuyi Li, Xinyu Wei, Yu Zhao, Daowan Lai, Ligang Zhou, Mingan Wang
Abstract
The first total syntheses of Palmarumycin BG1–3, BG5–6, C<sub>1</sub>and Guignardin E were achieved. These compounds displayed significant inhibition activities against HCT116, U87-MG, HepG2, BGC823 and PC9 cell lines.
Topics & Concepts
ChemistryMicrobial Natural Products and BiosynthesisChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacology