SIRT7 Downregulation Promotes Breast Cancer Metastasis Via LAP2α-Induced Chromosomal Instability
Qin Huo, Siqi Chen, Jialang Zhuang, Chuntao Quan, Yue Wang, Ni Xie
Abstract
evidence revealed that SIRT7 promotes breast cancer metastasis through the SIRT7/LAP2α axis. In summary, SIRT7 interacts with LAP2α to regulate CIN and metastasis in breast cancer, and inhibition of SIRT7/LAP2α axis represents a potential therapeutic strategy for preventing breast cancer metastasis.
Topics & Concepts
Gene knockdownCancer researchBreast cancerMetastasisCancerBiologyMedicineCell cultureInternal medicineGeneticsRNA regulation and diseaseCRISPR and Genetic EngineeringPARP inhibition in cancer therapy