Iron(III) Chloride as a Mild Catalyst for the Dearomatizing Cyclization of <i>N</i>-Acylindoles
Jingyu Zhang, Jing Li, Jas S. Ward, Khai‐Nghi Truong, Kari Rissanen, Markus Albrecht
Abstract
A catalytic approach for the preparation of indolines by dearomatizing cyclization is presented. FeCl3 acts as a catalyst to afford tetracyclic 5a,6-dihydro-12H-indolo[2,1-b][1,3]benzoxazin-12-ones in good yields. The cyclization also proceeds with tosylamides forming C–N bonds in 53% yield.
Topics & Concepts
ChemistryYield (engineering)CatalysisChlorideMedicinal chemistryOrganic chemistryCombinatorial chemistryMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesSynthesis and Biological Evaluation