Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells
Chenggong Tu, Zhimin Du, Hui Zhang, Yueyuan Feng, Yu-Jun Qi, Yongjiang Zheng, Jinbao Liu, Jinheng Wang
Abstract
Clathrin- and caveolin-dependent endocytosis and macropinocytosis are the predominant routes of sEV-mediated communication between BMSCs and MM cells, and inhibiting endocytosis attenuates sEV-induced reduction of chemosensitivity to bortezomib, and thus enhances its anti-MM properties.
Topics & Concepts
BortezomibEndocytic cycleExtracellular vesiclesMultiple myelomaExtracellularChemistryCancer researchExtracellular vesicleCell biologyVesiclePharmacologyMedicineEndocytosisMicrovesiclesBiologyCellInternal medicineBiochemistryMembraneGenemicroRNAPeptidase Inhibition and AnalysisMultiple Myeloma Research and TreatmentsDiabetes Treatment and Management