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Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells

Myeong Joon Kim, Kyung Soo Kim, Hyo Jin Park, Gil‐Ran Kim, Kyeong Hee Hong, Ji Hoon Oh, Jimin Son, Dong Jin Park, Dahae Kim, Je‐Min Choi, Insuk Lee, Sang‐Jun Ha

2022Nature Immunology83 citationsDOI

Topics & Concepts

Tumor microenvironmentBiologyImmune systemCD8Cancer researchCytotoxic T cellT cellPD-L1FOXP3Regulatory T cellImmunologyCell biologyImmunotherapyIL-2 receptorIn vitroGeneticsImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersImmune cells in cancer
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells | Litcius