A visible and near-infrared dual-fluorescent probe for discrimination between Cys/Hcy and GSH and its application in bioimaging
Ruixi Li, Habtamu Kassaye, Yanping Pan, Yuanzhi Shen, Weiqing Li, Yu‐Ru Cheng, Jingxuan Guo, Yue Xu, Hongping Yin, Zhenwei Yuan
Abstract
= 470 nm). The probe Cy2 is operable in human serum samples, thus holding promise for its diagnosis-related application. Notably, the results of fluorescence microscopy imaging indicated that Cy2 is suitable for visualization of exogenous and endogenous biothiols in living cells. Furthermore, desirable results were obtained when the probe Cy2 was applied for bioimaging in tumor-bearing mice and acute liver injury (ALI) mice models, which revealed encouraging clinical values of this probe.
Topics & Concepts
FluorescenceInfraredChemistryDual (grammatical number)Visible spectrumBiophysicsGlutathioneCysteinePhotochemistryNanotechnologyBiochemistryOptoelectronicsMaterials scienceBiologyOpticsPhysicsEnzymeLiteratureArtMolecular Sensors and Ion DetectionSulfur Compounds in BiologyAdvanced biosensing and bioanalysis techniques