KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
Yuhang Jiang, Fengfeng Li, Bowen Gao, Mengjun Ma, Chen Meng, Yanfeng Wu, Weidong Zhang, Yangbai Sun, Sanhong Liu, Huiyong Shen
Abstract
Collectively, we elucidated that upregulated KDM6B facilitates tumor metastasis in OS via modulating LDHA expression. Our findings deepen the recognition of OS metastasis mechanism and suggest that KDM6B might be a new potential therapeutic target for the treatment of OS (especially highly metastatic OS).
Topics & Concepts
DemethylaseCancer researchMetastasisGene knockdownOsteosarcomaBiologyChemistryCancerHistoneApoptosisGeneBiochemistryGeneticsEpigenetics and DNA MethylationCancer-related molecular mechanisms researchHistone Deacetylase Inhibitors Research