Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice
Jun Seok Son, Liang Zhao, Yanting Chen, Ke Chen, Song Ah Chae, Jeanene M. de Avila, Hongyang Wang, Mei‐Jun Zhu, Zhihua Jiang, Min Du
Abstract
promoter and BAT development and prevented obesity of offspring when challenged with a high-energy diet. Apelin, an exerkine, was elevated in both maternal and fetal circulations due to exercise, and maternal administration of apelin mimicked the beneficial effects of exercise on fetal BAT development and offspring metabolic health. Together, maternal exercise enhances thermogenesis and the metabolic health of offspring mice, suggesting that the sedentary lifestyle during pregnancy contributes to the obesity epidemic in modern societies.
Topics & Concepts
AdipogenesisOffspringApelinEndocrinologyInternal medicineBiologyMedicinePregnancyAdipose tissueGeneticsReceptorApelin-related biomedical researchAdipose Tissue and MetabolismLipid metabolism and disorders