Bacteriophage-Antibiotic Combination Strategy: an Alternative against Methicillin-Resistant Phenotypes of Staphylococcus aureus
Razieh Kebriaei, Katherine L. Lev, Taylor Morrisette, Kyle Stamper, Jacinda C. Abdul‐Mutakabbir, Susan M. Lehman, Sandra Morales, Michael J. Rybak
Abstract
Comparative time-kill experiments with Staphylococcus aureus bacteriophage (phage) Sb-1 alone and phage-antibiotic combinations (PACs) against two methicillin-resistant S. aureus (MRSA) strains have shown synergy with both daptomycin-phage and vancomycin-phage combinations. PACs prevented development of phage resistance and demonstrated bactericidal activity for all triple combinations. In addition, the extracellular membrane vesicle (MV) formation and the potential impact of phage on MV suppression were examined.
Topics & Concepts
BacteriophageStaphylococcus aureusMicrobiologyDaptomycinAntibioticsPhage therapyBiologyAntibiotic resistanceMethicillin-resistant Staphylococcus aureusVirologyVancomycinPhage typingBacteriaEscherichia coliGeneticsGeneSerotypeBacteriophages and microbial interactionsBacterial Infections and VaccinesBacterial Genetics and Biotechnology