Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice
Takashi Nishina, Yutaka Deguchi, Mika Kawauchi, Xiyu Chen, Soh Yamazaki, Tetuo Mikami, Hiroyasu Nakano
Abstract
-positive myeloid cells. These findings indicate that fibroblast-produced IL-11 plays an important role in protecting the mucosal epithelium in acute colitis. Myeloid cell-derived ROS contribute to the attenuation of colitis through the production of IL-11.
Topics & Concepts
ColitisInflammatory bowel diseaseImmunologyIntestinal epitheliumStromal cellChemistryInterleukin 11Reactive oxygen speciesInterleukinCancer researchCytokineBiologyCell biologyMedicineEpitheliumPathologyDiseaseImmune Cell Function and InteractionImmune Response and InflammationIL-33, ST2, and ILC Pathways