Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome
Xinyu Yang, Ning Zhan, Yang Jin, Hanzhi Ling, Chipeng Xiao, Zhen Xie, Hao Zhong, Xinxin Yu, Runhua Tang, Jinglan Ma, Ju-Bo Guan, Guoyu Yin, Gan Wu, Liangjing Lu, Jianguang Wang
Abstract
Recovery of γδTreg/γδT17 cell balance was a novel mechanism by which TOF alleviated RA. Meanwhile, NLRP3 played a pivotal role in the process of TOF-mediated γδT17 cell activation.
Topics & Concepts
InflammasomeTofacitinibRheumatoid arthritisInflammationMedicineArthritisImmunologyJanus kinaseChemistryCancer researchCytokineCytokine Signaling Pathways and InteractionsInflammasome and immune disordersAutoimmune and Inflammatory Disorders Research