Expanding Access to Remdesivir via an Improved Pyrrolotriazine Synthesis: Supply Centered Synthesis
Dinesh J. Paymode, Flávio S. P. Cardoso, Toolika Agrawal, John W. Tomlin, Daniel W. Cook, Justina M. Burns, Rodger W. Stringham, Joshua D. Sieber, B. Frank Gupton, David R. Snead
Abstract
is an important precursor to remdesivir. Initial results toward an efficient synthesis are disclosed consisting of sequential cyanation, amination, and triazine formation beginning from pyrrole. This route makes use of highly abundant, commoditized raw material inputs. The yield of triazine was doubled from 31% to 59%, and the synthetic step count was reduced from 4 to 2. These efforts help to secure the remdesivir supply chain.
Topics & Concepts
CyanationChemistryYield (engineering)AminationCombinatorial chemistryReductive amination1,3,5-TriazineOrganic chemistryCatalysisMaterials scienceMetallurgyClick Chemistry and ApplicationsSynthesis and Biological EvaluationChemical Reaction Mechanisms