<i>HAR1</i> : An Insight Into lncRNA Genetic Evolution
Ella V. Waters, Perla Pucci, Mark C. Hirst, Simon Chapman, Yuzhuo Wang, Francesco Crea, Christopher J. Heath
Abstract
Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.