Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis
Min Shi, In Hyuk Bang, Chang Yeob Han, Dae Ho Lee, Byung‐Hyun Park, Eun Ju Bae
Abstract
Statin induces miR-495 to suppress Sirt6 expression, which leads to enhancement of FoxO1-mediated hepatic gluconeogenesis. Thus, Sirt6 activation may offer a promising strategy for preventing statin-induced hyperglycemia.
Topics & Concepts
Sirtuin 1FOXO1SirtuinGluconeogenesisStatinChemistryCell biologyInternal medicineMedicineEndocrinologyCancer researchBiologyDownregulation and upregulationBiochemistryPhosphorylationMetabolismNAD+ kinaseEnzymeGeneProtein kinase BMitochondrial Function and PathologyLiver Disease Diagnosis and TreatmentFOXO transcription factor regulation