A single locus determines praziquantel response in <i>Schistosoma mansoni</i>
Frédéric D. Chevalier, Winka Le Clecʼh, Matthew Berriman, Timothy J. C. Anderson
Abstract
We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.
Topics & Concepts
PraziquantelGenome-wide association studyLocus (genetics)BiologySchistosoma mansoniGeneticsQuantitative trait locusGenomeComputational biologyGeneSingle-nucleotide polymorphismGenotypeSchistosomiasisImmunologyHelminthsParasites and Host InteractionsTrace Elements in HealthParasite Biology and Host Interactions