Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
Feifei Wu, Huiyu Li, Qi An, Yaoliang Sun, Jinghua Yu, Wenting Cao, Pu Sun, Xingxing Diao, Ling‐Hua Meng, Shilin Xu
Topics & Concepts
Jurkat cellsChemistryCancer immunotherapyImmunotherapyT cellKinaseHaematopoiesisCancer researchT-cell receptorCell biologyCancerBiologyBiochemistryStem cellImmunologyImmune systemGeneticsCAR-T cell therapy researchChronic Lymphocytic Leukemia ResearchImmune Cell Function and Interaction