Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study
Ruifeng Wang, Xiangxin Zhao, Sijia Yu, Yixuan Chen, Hengxian Cui, Tianxiao Wu, Chenzhou Hao, Dongmei Zhao, Maosheng Cheng
Topics & Concepts
ChemistryDocking (animal)IC50KinaseTyrosine kinaseCytotoxicityApoptosisCell culturePyrimidineStereochemistryBiochemistrySignal transductionIn vitroBiologyNursingGeneticsMedicineCell Adhesion Molecules ResearchMelanoma and MAPK PathwaysHER2/EGFR in Cancer Research