Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?
Collin M. Bantle, Warren D. Hirst, Andreas Weihofen, Evgeny Shlevkov
Abstract
Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD). Astrocytes are the most abundant glial cell type in the brain and are thought to play a pivotal role in the progression of PD. Emerging evidence suggests that many astrocytic functions, including glutamate metabolism, Ca 2+ signaling, fatty acid metabolism, antioxidant production, and inflammation are dependent on healthy mitochondria. Here, we review how mitochondrial dysfunction impacts astrocytes, highlighting translational gaps and opening new questions for therapeutic development.
Topics & Concepts
Parkinson's diseaseMitochondrionGlutamate receptorAstrocyteNeuroscienceDiseaseBiologyInflammationNeuroinflammationLRRK2Cell biologyMedicineCentral nervous systemImmunologyPathologyGeneticsReceptorNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNuclear Receptors and Signaling