<i>atpE</i> Mutation in <i>Mycobacterium tuberculosis</i> Not Always Predictive of Bedaquiline Treatment Failure
Laure Fournier Le Ray, Alexandra Aubry, Wladimir Sougakoff, Matthieu Revest, J. Robert, Isabelle Bonnet, Nicolas Véziris, F. Morel
Abstract
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.
Topics & Concepts
BedaquilineMycobacterium tuberculosisTuberculosisGenotypeMutationPhenotypePredictive valueVirologyBiologyMedicineMicrobiologyGeneticsInternal medicinePathologyGeneTuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosis