An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs
Weijian Li, Xuejing Zhu, Tianjie Yuan, Zhenyu Wang, Zhengqian Bian, Hongshu Jing, Xiao Shi, Cai–Yang Chen, Gongbo Fu, Weijian Huang, Yao-Ping Shi, Qian Liu, Min Zeng, Hong‐Dan Zhang, Hongping Wu, Weifeng Yu, Bo Zhai, He‐Xin Yan
Abstract
= 0.003). The blood ammonia concentrations, as well as the biochemical and coagulation indices, were reduced in Ali-BAL-treated pigs. Ali-BAL treatment attenuated liver damage, ameliorated inflammation, and enhanced liver regeneration in the ALF porcine model and could be considered as a potential therapeutic avenue for patients with ALF.
Topics & Concepts
Bioartificial liver deviceProgenitor cellExtracorporealLiver failureLiver regenerationHuman liverMedicineRegeneration (biology)InflammationStem cellCell biologyHepatocyteInternal medicineBiologyIn vitroBiochemistryLiver physiology and pathologyTissue Engineering and Regenerative MedicineOrgan Transplantation Techniques and Outcomes