Genetic adjuvants: A paradigm shift in vaccine development and immune modulation
Karīna Spunde, Ksenija Korotkaja, Irina Sominskaya, Anna Zajakina
Abstract
T cell activation in immunocompromised populations. This review explores the potential of genetically encoded adjuvants, including cytokines, chemokines, and other immune modulators. By comparing these adjuvants to traditional formulations, we highlight their capacity to address the limitations of modern vaccines while discussing their integration with emerging technologies like RNA-based vaccines. As genetic adjuvants advance toward clinical application, understanding their mechanisms and optimizing their delivery is pivotal to unlocking next-generation immunization strategies.
Topics & Concepts
Immune modulationImmune systemParadigm shiftVaccine adjuvantAdjuvantBiologyImmunologyPhysicsQuantum mechanicsvaccines and immunoinformatics approachesinterferon and immune responsesInfluenza Virus Research Studies