Rapid Construction of Substituted Dihydrothiophene Ureidoformamides at Room Temperature Using Diisopropyl Ethyl Ammonium Acetate: A Green Perspective
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Vidya S. Dofe, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Charansingh H. Gill
Abstract
-carbamoyl acetamide)-substituted 2,3-dihydrothiophene analogs were synthesized, and selected samples were chosen for testing their in vitro antibacterial and antifungal activities. Furthermore, a molecular docking study against sterol 14α-demethylase could provide valuable insight into the mechanism of antifungal action providing an opportunity for structure-based lead optimization.
Topics & Concepts
Ammonium acetateAcetamideIonic liquidAtom economyChemistryGreen chemistryCombinatorial chemistryAntifungalAcetophenoneEnvironmentally friendlyOrganic chemistryHigh-performance liquid chromatographyCatalysisDermatologyBiologyEcologyMedicineMulticomponent Synthesis of HeterocyclesChemical Synthesis and ReactionsChemistry and Chemical Engineering