Curing Cancer with Nanotherapy Continues to be an Elusive Goal
Priyanka Ray
Abstract
Nanotechnology has aimed to address limitations of new drug design by “repackaging” FDA approved drugs without compromising their therapeutic benefits while suppressing undesired side effects suffered by patients undergoing chemotherapy. The major hurdles faced by small molecular drugs in treating cancer include hydrophobicity, rapid hepatic and renal clearance, short circulation time, off target toxicity and drug resistance. Most of these factors are addressed using nano formulations comprising lipids or polymers and simultaneously striving to enhance the therapeutic index of chemotherapeutic drugs.
Topics & Concepts
DrugMedicineSystemic circulationPharmacologyCancer therapyCancerTherapeutic indexIntensive care medicineChemotherapeutic drugsInternal medicineNanoparticle-Based Drug DeliveryCancer Treatment and PharmacologyNanoplatforms for cancer theranostics