Discrimination of antibiotic-resistant Gram-negative bacteria with a novel 3D nano sensing array
Jianyu Yang, Xindi Jia, Xiaoyan Wang, Meng-Xian Liu, Mingli Chen, Ting Yang, Jianhua Wang
Abstract
A novel sensor array based on a (+)AuNP/AuNC nanocomposite was constructed for the selective discrimination of 10 types of Gram-negative bacteria (including 3 types of antibiotic-resistant strains) at a low concentration level of OD600 = 0.015. By recognizing the triple optical patterns of Gram-negative bacteria with the assistance of LDA, the sensor array is able to group the bacteria with respect to their species to each other.
Topics & Concepts
GramBacteriaGram-negative bacteriaAntibioticsMicrobiologyGram-positive bacteriaAntibiotic resistanceNano-ChemistryBiologyMaterials scienceEscherichia coliBiochemistryGeneGeneticsComposite materialBiosensors and Analytical DetectionAdvanced biosensing and bioanalysis techniquesAdvanced Chemical Sensor Technologies