Dynamic Combinatorial Optimization of <i>In Vitro</i> and <i>In Vivo</i> Heparin Antidotes
Daniel Carbajo, Yolanda Pérez, Marta Guerra‐Rebollo, Eva Prats, Jordi Bujons, Ignacio Alfonso
Abstract
blood coagulation assays with mice show that the optimized molecules are potent antidotes with potential use as heparin reversal drugs. Overall, these results underscore the power of dynamic combinatorial chemistry targeting complex and elusive biopolymers.
Topics & Concepts
ChemistryHeparinIn vivoEx vivoIn vitroCombinatorial chemistryMacromoleculePharmacologyBiochemistryBiotechnologyBiologyMedicineProteoglycans and glycosaminoglycans researchChemical Synthesis and AnalysisCarbohydrate Chemistry and Synthesis