Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study
Seth D. Crockett, Aasma Shaukat, Olivia Delau, Elena M. Stoffel, Timothy R. Church, Sapna Syngal, Robert S. Bresalier
Abstract
INTRODUCTION: Risk factors for serrated polyps (SPs) are not well understood. METHODS: Multivariable analyses of data from a multicenter colonoscopy-based study estimated odds ratios for having either a sessile serrated lesion or traditional serrated adenoma according to participant characteristics. RESULTS: Six thousand seventy-eighty participants were included in the analyses (565 with either a sessile serrated lesion or traditional serrated adenoma). White race was associated with a higher risk of SPs compared with Black race (adjusted odds ratio 4.64, 95% confidence interval 1.89-11.41). Obesity and current smoking were also associated with a higher risk of SPs. DISCUSSION: White race, smoking, and obesity are risk factors for precancerous SPs.