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The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of the TET2/NLRP3 inflammasome signaling pathway

Mingwei Fu, Zirong Lan, Yuanzhi Ye, Yuan Gong, Qingchun Liang, Mingxi Li, Liyun Feng, An Chen, Qianqian Dong, Yining Li, Siyi Wang, Xiaoyu Liu, Xiuli Zhang, Jing‐Song Ou, Lihe Lu, Jianyun Yan

2025Kidney International13 citationsDOI

Topics & Concepts

Vascular smooth muscleCalcificationDownregulation and upregulationEndocrinologyInternal medicineInflammasomeBiologyMedicineBiochemistryInflammationGeneSmooth muscleParathyroid Disorders and TreatmentsDermatological and Skeletal DisordersAortic Thrombus and Embolism
The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of the TET2/NLRP3 inflammasome signaling pathway | Litcius