DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-<i>tert</i>-butyl Dicarbonate
Hui Chen, Peng Li, Rongfei Qin, Hong Yan, Gang Li, Haihong Huang
Abstract
-methoxybenzyl (PMB)-activated heterocyclization could smoothly proceed at room temperature instead of the microwave condition. This strategy is compatible with a variety of substrates with different functional groups. Furthermore, this protocol was utilized to smoothly prepare Zenarestat with a total yield of 70%.
Topics & Concepts
QuinazolineCatalysisYield (engineering)ChemistryCombinatorial chemistryReaction conditionsMedicinal chemistryOrganic chemistryMaterials scienceMetallurgyQuinazolinone synthesis and applicationsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryMulticomponent Synthesis of Heterocycles