Urolithins: potential biomarkers of gut dysbiosis and disease stage in Parkinson's patients
María Romo‐Vaquero, Emiliano Fernández‐Villalba, Ana Luisa Gil-Martínez, Lorena Cuenca‐Bermejo, Juan Carlos Espı́n, María Trinidad Herrero, María V. Selma
Abstract
). Besides, their microbiome was characterized by predictive functions of lipopolysaccharide biosynthesis and metabolism of glutathione, cysteine and methionine that could indirectly reflect the gut pro-inflammatory status. Urolithin detection in urine is a feasible, non-invasive and fast approach that can reflect gut microbiome dysbiosis and intestinal inflammation in Parkinson's disease patients. Our current study could provide novel strategies for improving diagnostics, and for preventing and treating disease progression in microbiota-based interventions.
Topics & Concepts
DysbiosisGut floraMicrobiomeDiseaseMedicineAkkermansiaImmunologyBiologyInternal medicineBioinformaticsBacteriaLactobacillusGeneticsPomegranate: compositions and health benefitsNutrition and Health in AgingSesame and Sesamin Research