Tumour associated vasculature-on-a-chip for the evaluation of microbubble-mediated delivery of targeted liposomes
Matthew D. Bourn, Safoura Zahed Mohajerani, Georgia Mavria, Nicola Ingram, P. Louise Coletta, Stephen D. Evans, Sally A. Peyman
Abstract
may be a potential target for the delivery of drugs specifically to tumour vasculature. Furthermore, the use of microbubbles (MBs) and ultrasound (US) to further enhance the delivery of LSs to TCM-conditioned vasculature was investigated. Quantification of fluorescent LS accumulation post-perfusion of the vascular network showed 3-fold increased accumulation with the use of MBs and US, suggesting that targeted LS delivery could be further improved with the use of locally administered MBs and US.
Topics & Concepts
LiposomeMicrobubblesBiomedical engineeringDelivery systemNanotechnologyMedicineCancer researchPharmacologyMaterials scienceUltrasoundRadiologyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsCharacterization and Applications of Magnetic Nanoparticles