CCBE1 promotes tumor lymphangiogenesis and is negatively regulated by TGFβ signaling in colorectal cancer
Jinglue Song, Wei‐Fan Chen, Xuewei Cui, Zhenyu Huang, Dongpeng Wen, Yili Yang, Wei Yu, Long Cui, Chen‐Ying Liu
Abstract
: Our results demonstrate the protumorigenic role of CCBE1 in promoting lymphangiogenesis and lymphatic metastasis in CRC, revealing a new mechanism by which loss of TGF-β signaling promotes CRC metastasis.
Topics & Concepts
LymphangiogenesisCancer researchBiologyVascular endothelial growth factor CLymphatic EndotheliumMetastasisLymphatic vesselLymphatic systemPathologyVascular endothelial growth factorVascular endothelial growth factor ACancerImmunologyMedicineGeneticsVEGF receptorsLymphatic System and DiseasesKruppel-like factors researchWnt/β-catenin signaling in development and cancer