Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors
Ismail M. M. Othman, Zahra M. Al-Amshany, Nada Y. Tashkandi, Mohamed A. M. Gad‐Elkareem, Somaia S. Abd El‐Karim, Eman S. Nossier
Abstract
Deregulation of various protein kinases is considered as one of the important factors resulting in cancer development and metastasis, thus multi-targeting the kinase family is one of the most important strategies in current cancer therapy.
Topics & Concepts
ChemistryThiazoleKinaseCancer cellCell cycleContext (archaeology)Docking (animal)ApoptosisPharmacologyBiochemistryStereochemistryCancerBiologyMedicinePaleontologyNursingGeneticsSynthesis and biological activityClick Chemistry and ApplicationsQuinazolinone synthesis and applications