IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
Ellen Chang, Matthew Smith-Cohn, Benita Tamrazi, Jianling Ji, Mark D. Krieger, Matthias Holdhoff, Charles G. Eberhart, Ashley Margol, Jennifer Cotter
Abstract
Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH-mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.
Topics & Concepts
Isocitrate dehydrogenaseBrainstemIDH1Young adultMutantMedicineGliomaPathologyPediatricsBiologyInternal medicineGeneticsCancer researchGeneEnzymeBiochemistryGlioma Diagnosis and TreatmentMeningioma and schwannoma managementBone Tumor Diagnosis and Treatments