Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA
Asmaa H. Mohamed, Sara M. Mostafa, Ashraf A. Aly, Alaa A. Hassan, Esraa M. Osman, AbdElAziz A. Nayl, Alan B. Brown, Elshimaa M. N. Abdelhafez
Abstract
In an attempt to develop effective and safe antibacterial agents, thiazinanones bearing the quinolone scaffold were prepared by reaction of the corresponding (quinolinylmethylene)hydrazinecarbothioamides with 2,3-diphenylcycloprop-2-enone.
Topics & Concepts
QuinoloneQuinolineCombinatorial chemistryDocking (animal)ChemistryScaffoldAntibacterial activityStereochemistryBacteriaOrganic chemistryBiologyBiochemistryAntibioticsComputer scienceMedicineGeneticsNursingDatabasePhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Biological EvaluationSynthesis and biological activity